How Your Gut and Brain Work Together to Support Your Heart?
by Anna Sandhu | Mar 02, 2026
Reviewed by Dr. Arun, M.Pharm., PGDRA, Ph.D.
Your gut and your heart are more connected than you may think. A new study looked at how gut bacteria can affect heart health, especially when the gut is out of balance.
When your gut bacteria are not balanced, it is called dysbiosis. This can happen due to poor diet, stress, or illness. Dysbiosis may lead to harmful changes in the body, including effects on the heart.
The researchers focused on a natural compound called indole-3 acetate. This compound is made when gut bacteria break down certain nutrients from food.
The scientists asked two main questions:
- Can this gut-derived compound help protect the heart?
- How does the gut communicate with the heart during imbalance?
Here are the key findings:
- The study found that indole-3 acetate may help reduce harmful effects caused by gut imbalance.
- It works through special nerve cells in the brain called Hcrt neurons. These neurons help control body functions like energy and heart activity.
- When gut balance is disturbed, signals from the gut can affect these brain cells. This can lead to changes in heart function.
- The compound helped improve communication between the gut, brain, and heart. This may support better heart function during stress caused by gut imbalance.
- It showed a role in helping reduce diastolic dysfunction, a condition where the heart has trouble relaxing properly.
Why this matters:
- Your gut health can influence more than digestion. It can affect important organs like your heart.
- When the gut is balanced, it produces helpful compounds that support the body.
- When it is not balanced, it may send harmful signals that affect heart function.
- Supporting gut health may also support heart health in the long run.
In short:
This study shows that your gut, brain, and heart are closely connected. Compounds made by gut bacteria may help support heart function, especially when the gut is out of balance.
In simple terms, a healthy gut can help send better signals to your body, including your heart.
This research helps us better understand how improving gut health may support overall wellness, including heart health.
More information: Indole-3 Acetate Limits Dysbiosis-Driven Diastolic Failure via Hcrt Neurons. DOI: https://doi.org/10.1161/CIRCRESAHA.125.326990