Can Gut Bacteria Affect Stress Levels? What Science Says
by Anna Sandhu | Apr 06, 2026
Reviewed by Dr. Arun, M.Pharm., PGDRA, Ph.D.
This study looked at how the bacteria in your gut may affect how your body reacts to stress. Your gut is home to trillions of tiny microbes. These microbes help with digestion, immunity, and even send signals to your brain.
Researchers wanted to understand if people with different gut bacteria react to stress in different ways.
To study this, they tested healthy adults. Some people were put in a stressful situation, while others did a calm task. The researchers measured stress in two ways. First, they checked cortisol levels, which is a stress hormone found in saliva. Second, they asked people how stressed they felt. They also collected stool samples to study gut bacteria.
The results were interesting.
People who had more diverse gut bacteria showed a stronger stress response. This means their bodies reacted more when they were under pressure. At first, this may sound like a bad thing. But it is not always negative. A stronger stress response can mean the body is alert and ready to handle challenges.
The study also looked at special compounds made by gut bacteria. These are called short-chain fatty acids. They are made when bacteria break down fiber from food. These compounds can affect the brain and body in many ways.
Two important types were studied, butyrate and propionate.
People whose gut bacteria made more butyrate had a stronger stress response. But people with more propionate had a lower stress response. This shows that not all gut bacteria act the same way. Different types can affect stress in different ways.
Overall, the study shows that gut health is closely linked to how we respond to stress. It also suggests that what we eat and how we live may shape our gut bacteria, and this may influence our stress levels.
In the future, improving gut health through diet or supplements may help support better stress balance. But more research is still needed to fully understand this connection.
More Information: Gut microbial diversity and inferred capacity to produce short-chain fatty acids are associated with acute stress reactivity in healthy adults. DOI: https://doi.org/10.1016/j.ynstr.2026.100807